Philippe Marin Selected Research

serotonin 6 receptor

1/2023	Impact of 5-HT6 Receptor Subcellular Localization on Its Signaling and Its Pathophysiological Roles.
1/2023	The Constitutive Activity of Spinal 5-HT6 Receptors Contributes to Diabetic Neuropathic Pain in Rats.
1/2023	Spatiotemporal dynamics of 5-HT6 receptor ciliary localization during mouse brain development.
9/2022	Early 5-HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse.
10/2021	Neuropathic pain-alleviating activity of novel 5-HT6 receptor inverse agonists derived from 2-aryl-1H-pyrrole-3-carboxamide.
1/2021	Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties.
1/2021	Blockade of Serotonin 5-HT6 Receptor Constitutive Activity Alleviates Cognitive Deficits in a Preclinical Model of Neurofibromatosis Type 1.
10/2020	mTOR activation by constitutively active serotonin6 receptors as new paradigm in neuropathic pain and its treatment.
1/2020	The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies.
1/2020	Early 5-HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse.

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Philippe Marin Research Topics

Disease

9	Cognitive Dysfunction 01/2023 - 10/2008
8	Hyperalgesia 01/2023 - 08/2010
8	Neuralgia (Stump Neuralgia) 01/2023 - 08/2010
7	Schizophrenia (Dementia Praecox) 01/2023 - 10/2012
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 12/2012
7	Mental Disorders (Mental Disorder) 01/2023 - 01/2012
6	Neoplasms (Cancer) 05/2024 - 09/2005
5	Neurobehavioral Manifestations 01/2023 - 01/2020
4	Psychotic Disorders (Schizoaffective Disorder) 01/2021 - 01/2012
4	Memory Disorders (Memory Loss) 01/2021 - 01/2016
4	Alzheimer Disease (Alzheimer's Disease) 12/2020 - 01/2013
3	Inflammation (Inflammations) 05/2024 - 01/2013
3	Pain (Aches) 01/2017 - 08/2010
2	Stroke (Strokes) 03/2024 - 01/2020
2	Ischemic Stroke 03/2024 - 01/2020
2	Autism Spectrum Disorder 01/2023 - 06/2013
2	Marijuana Abuse (Cannabis Abuse) 09/2022 - 01/2020
2	Glioma (Gliomas) 01/2022 - 09/2015
2	Tauopathies 01/2021 - 01/2020
2	Dementia (Dementias) 01/2021 - 01/2016
2	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2021 - 10/2016
2	Nervous System Diseases (Neurological Disorders) 01/2020 - 10/2008
2	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 09/2015
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/2013 - 01/2010
1	Multiple Sclerosis 05/2024
1	Schmid-Fraccaro syndrome 05/2024
1	Frontotemporal Dementia (Semantic Dementia) 01/2021
1	Peripheral Nervous System Diseases (PNS Diseases) 10/2020
1	Neoplasm Metastasis (Metastasis) 12/2019
1	Nervous System Neoplasms (Neoplasms, Nervous System) 10/2016
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2016
1	Brain Neoplasms (Brain Tumor) 10/2015
1	Epilepsy (Aura) 10/2015

Drug/Important Bio-Agent (IBA)

17	Proteins (Proteins, Gene)FDA Link 05/2024 - 03/2005
14	Serotonin (5 Hydroxytryptamine)IBA 01/2023 - 09/2008
12	serotonin 6 receptorIBA 01/2023 - 10/2012
6	Biomarkers (Surrogate Marker)IBA 05/2024 - 09/2005
6	5-HT2A Serotonin Receptor (5 HT2A Receptor)IBA 01/2017 - 08/2010
4	Analgesics (Analgesic Drugs)IBA 01/2023 - 01/2013
4	LigandsIBA 01/2023 - 05/2013
4	Antidepressive Agents (Antidepressants)IBA 01/2017 - 08/2010
3	Hallucinogens (Psychedelics)IBA 01/2022 - 01/2012
3	Antipsychotic Agents (Antipsychotics)IBA 11/2019 - 01/2012
3	quinolineIBA 01/2019 - 05/2013
3	Phencyclidine (Angel Dust)IBA 01/2018 - 10/2012
3	Peptides (Polypeptides)IBA 01/2017 - 08/2008
3	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2017 - 08/2010
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2023 - 10/2020
2	Cell-Penetrating PeptidesIBA 01/2023 - 10/2020
2	Sirolimus (Rapamycin)FDA Link 01/2023 - 10/2012
2	Conditioned Culture MediaIBA 01/2022 - 09/2015
2	Phosphotransferases (Kinase)IBA 10/2021 - 08/2008
2	Serotonin ReceptorsIBA 01/2021 - 01/2012
2	Neurofibromin 1 (Neurofibromin)IBA 01/2021 - 10/2016
2	Scopolamine (Hyoscine)FDA Link 12/2020 - 01/2018
2	Amyloid (Amyloid Fibrils)IBA 01/2020 - 01/2013
2	Chemokine ReceptorsIBA 01/2020 - 12/2019
2	ProteomeIBA 01/2020 - 10/2008
2	Glutamic Acid (Glutamate)FDA Link 11/2019 - 05/2013
2	Fluoxetine (Prozac)FDA LinkGeneric 01/2017 - 01/2013
1	Proteoglycans (Proteoglycan)IBA 05/2024
1	Syndecan-1 (Syndecan 1)IBA 05/2024
1	ChitinasesIBA 05/2024
1	Adenosine DeaminaseIBA 05/2024
1	Interleukin-6 (Interleukin 6)IBA 03/2024
1	Streptozocin (Streptozotocin)FDA Link 01/2023
1	IntegrinsIBA 01/2022
1	FibromodulinIBA 01/2022
1	Small Leucine-Rich ProteoglycansIBA 01/2022
1	Gq-G11 GTP-Binding Protein alpha Subunits (Gq Protein)IBA 01/2021
1	5-HT3 Serotonin Receptors (5 HT3 Receptor)IBA 01/2021
1	serotonin 7 receptorIBA 01/2021
1	tau Proteins (tau Protein)IBA 01/2021
1	Ondansetron (Zofran)FDA LinkGeneric 01/2021
1	ras ProteinsIBA 01/2021
1	Connexin 43 (Connexin43)IBA 01/2020
1	Dronabinol (THC)FDA LinkGeneric 01/2020
1	Threonine (L-Threonine)FDA Link 01/2020
1	Protein Isoforms (Isoforms)IBA 01/2020
1	Amyloid beta-PeptidesIBA 01/2020
1	pyrrolidineIBA 01/2019
1	Dopamine D3 ReceptorsIBA 01/2019
1	Nootropic Agents (Nootropics)IBA 01/2018
1	Donepezil (Aricept)FDA LinkGeneric 01/2018
1	compound 17IBA 01/2018
1	3- benzenesulfonyl- 8- piperazin- 1- ylquinolineIBA 01/2016
1	Mechanistic Target of Rapamycin Complex 1IBA 10/2015
1	Macrophage Colony-Stimulating FactorIBA 09/2015
1	Amino Acids FDA Link 09/2015
1	CytokinesIBA 09/2015
1	IsotopesIBA 09/2015
1	Insulin-Like Growth Factor Binding Protein 1IBA 09/2015
1	diethylamineIBA 05/2014
1	Psilocybin (Psilocibin)IBA 05/2014
1	Mescaline (Peyote)IBA 05/2014

Therapy/Procedure

3	Ligation 01/2023 - 01/2017
1	Therapeutics 01/2021
1	Thrombectomy 01/2020
1	Secondary Prevention 01/2020
1	Drug Therapy (Chemotherapy) 01/2016